Novel Treatments


When diagnosis is delayed, patients often experience persistent symptoms. Research into solutions has involved screening of existing drugs for activity against borrelia.

One drug identified in this process is disulfiram, a drug commonly used to address alcohol abuse. It was identified through high-throughput screening, has been found to be useful in documented case studies at a variety of doses, and is currently in clinical trials. Patients who have tried it have had success in treating Lyme disease. However, treatment protocols are still not entirely clear. Alcohol must be avoided, both ingested and topical, and one thing that has become clear is that it is important to go low and slow in order to avoid side-effects.

If your doctor prescribes disulfiram, useful information is available at:

Doctors should be aware of potential issues with neuropathy among Lyme patients which may be averted by using enteric-coated capsules:

Azlocillin and nitroxoline have also been shown to have potential for use in future.


Methylene blue has been found effective against bartonella in high-throughput screening and early experience shows it is useful in treating persistent Bartonella.  It is also active against Borrelia.

If your doctor prescribes this, more information is available at: