Brucella and Coxiella; if you don't look, you don't find

Published Date
Journal
Clinical Medicine (Lond)
Citation
15(1):91-2
DOI
10.7861/clinmedicine.15-1-91
Authors
Lambourne JR
Brooks T
Abstract

Brucella and Coxiella are similar; both are obligate intracellular, zoonotic pathogens with a broad geographic distribution. Infection in animals is usually asymptomatic, but causes fetal loss and therefore has significant economic impact. Human infection may be asymptomatic or give rise to either organ-specific or multi-system disease. Organism culture is challenging for Coxiella and can lack sensitivity for Brucella. Therefore, infection is most commonly diagnosed by serology, but this may be negative in early infection and serology results may be challenging to interpret. Both Brucella and Coxiella are typically susceptible to a wide range of antimicrobials, but long courses may be needed. 

Keywords: Brucella; Coxiella; diagnosis; fever; zoonosis.