< Back to Research Top Published Date 10/09/2019 Polymicrobial Nature of Tick-Borne Diseases Journal American Society for Microbiology Citation MBio. 2019 Sep 10;10(5). pii: e02055-19 DOI 10.1128/mBio.02055-19 Authors Sanchez-Vicente S, Tagliafierro T, Coleman JL, Benach JL, Tokarz R Abstract Tick-borne diseases have doubled in the last 12 years, and their geographic distribution has spread as well. The clinical spectrum of tick-borne diseases can range from asymptomatic to fatal infections, with a disproportionate incidence in children and the elderly. In the last few years, new agents have been discovered, and genetic changes have helped in the spread of pathogens and ticks. Polymicrobial infections, mostly in Ixodes scapularis, can complicate diagnostics and augment disease severity. Amblyomma americanum ticks have expanded their range, resulting in a dynamic and complex situation, possibly fueled by climate change. To document these changes, using molecular biology strategies for pathogen detection, an assessment of 12 microbes (9 pathogens and 3 symbionts) in three species of ticks was done in Suffolk County, New York. At least one agent was detected in 63% of I. scapularis ticks Borrelia burgdorferi was the most prevalent pathogen (57% in adults; 27% in nymphs), followed by Babesia microti (14% in adults; 15% in nymphs), Anaplasma phagocytophilum (14% in adults; 2% in nymphs), Borrelia miyamotoi (3% in adults), and Powassan virus (2% in adults). Polymicrobial infections were detected in 22% of I. scapularis ticks, with coinfections of B. burgdorferi and B. microti (9%) and of B. burgdorferi and A. phagocytophilum (7%). Three Ehrlichia species were detected in 4% of A. americanum ticks. The rickettsiae constituted the largest prokaryotic biomass of all the ticks tested and included Rickettsia amblyommatis, Rickettsia buchneri, and Rickettsia montanensis The high rates of polymicrobial infection in ticks present an opportunity to study the biological interrelationships of pathogens and their vectors. IMPORTANCE Tick-borne diseases have increased in prevalence in the United States and abroad. The reasons for these increases are multifactorial, but climate change is likely to be a major factor. One of the main features of the increase is the geographic expansion of tick vectors, notably Amblyomma americanum, which has brought new pathogens to new areas. The clinical spectrum of tick-borne diseases can range from asymptomatic to fatal infections, with a disproportionate incidence in children and the elderly. In addition, new pathogens that are cotransmitted by Ixodes scapularis have been discovered and have led to difficult diagnoses and to disease severity. Of these, Borrelia burgdorferi, the agent of Lyme disease, continues to be the most frequently transmitted pathogen. However, Babesia microti, Borrelia miyamotoi (another spirochete), Anaplasma phagocytophilum, and Powassan virus are frequent cotransmitted agents. Polymicrobial infection has important consequences for the diagnosis and management of tick-borne diseases. URL Previous https://mbio.asm.org/content/10/5/e02055-19 No Review Needed? Next

< Back to Research Top Published Date 14/01/2020 Lyme Aortitis Journal BMJ Case Reports Citation 13(1):e231957 DOI 10.1136/bcr-2019-231957. Authors Correia RR, Cruz F, Martin S, Andre ME Abstract A 72-year-old man was admitted with complaints of sudden-onset oppressive precordial pain radiating to the back for 1 hour. He had hypotension, peripheral cyanosis and cold extremities. An initial assessment was done and acute coronary syndrome was excluded. After the patient was admitted, he developed fever and increased levels of inflammatory markers. Data obtained from CT angiography and transoesophageal echocardiogram revealed diffuse parietal thickening of the arch and the descending thoracic aorta, as well as dilatation of the aortic root and the proximal ascending aorta. In addition, the test for Borrelia burgdorferi was positive, and the patient was diagnosed with Lyme vasculitis of the thoracic aorta. He was treated with doxycycline for 3 weeks. Two months later, the patient exhibited a Stanford type A aortic dissection (clinically stable), which was treated by prosthesis replacement. The patient has remained asymptomatic for 1 year after the episode, performing his routine daily activities. Keywords: cardiovascular system; infections. URL Previous https://casereports.bmj.com/content/13/1/e231957.long No Review Needed? Next

< Back to Research Top Published Date 09/10/2020 Classification of patients referred under suspicion of tick-borne diseases, Copenhagen, Denmark Journal Ticks and Tick-borne Diseases Citation 12(1):101591 DOI 10.1016/j.ttbdis.2020.101591 Authors Haahr R, Hansen K, Mens H, Lebech AM, Andersen AB, Fana V Abstract To provide better care for patients suspected of having a tick-transmitted infection, the Clinic for Tick-borne Diseases at Rigshospitalet, Copenhagen, Denmark was established. The aim of this prospective cohort study was to evaluate diagnostic outcome and to characterize demographics and clinical presentations of patients referred between the 1st of September 2017 to 31st of August 2019. A diagnosis of Lyme borreliosis was based on medical history, symptoms, serology and cerebrospinal fluid analysis. The patients were classified as definite Lyme borreliosis, possible Lyme borreliosis or post-treatment Lyme disease syndrome. Antibiotic treatment of Lyme borreliosis manifestations was initiated in accordance with the national guidelines. Patients not fulfilling the criteria of Lyme borreliosis were further investigated and discussed with an interdisciplinary team consisting of specialists from relevant specialties, according to individual clinical presentation and symptoms. Clinical information and demographics were registered and managed in a database. A total of 215 patients were included in the study period. Median age was 51 years (range 17-83 years), and 56 % were female. Definite Lyme borreliosis was diagnosed in 45 patients, of which 20 patients had erythema migrans, 14 patients had definite Lyme neuroborreliosis, six had acrodermatitis chronica atrophicans, four had multiple erythema migrans and one had Lyme carditis. Furthermore, 12 patients were classified as possible Lyme borreliosis and 12 patients as post-treatment Lyme disease syndrome. A total of 146 patients (68 %) did not fulfil the diagnostic criteria of Lyme borreliosis. Half of these patients (73 patients, 34 %) were diagnosed with an alternative diagnosis including inflammatory diseases, cancer diseases and two patients with a tick-associated disease other than Lyme borreliosis. A total of 73 patients (34 %) were discharged without sign of somatic disease. Lyme borreliosis patients had a shorter duration of symptoms prior to the first hospital encounter compared to patients discharged without a specific diagnosis (p<0.001). When comparing symptoms at presentation, patients discharged without a specific diagnosis suffered more often from general fatigue and cognitive dysfunction. In conclusion, 66 % of all referred patients were given a specific diagnosis after ended outpatient course. A total of 32 % was diagnosed with either definite Lyme borreliosis, possible Lyme borreliosis or post-treatment Lyme disease syndrome; 34 % was diagnosed with a non-tick-associated diagnosis. Our findings underscore the complexity in diagnosing Lyme borreliosis and the importance of ruling out other diseases through careful examination. URL Previous https://www.sciencedirect.com/science/article/pii/S1877959X2030460X?via%3Dihub= No Review Needed? Next

< Back to Research Top Published Date 01/08/2012 Probable late lyme disease: a variant manifestation of untreated Borrelia burgdorferi infection Journal BMC Infectious Diseases Citation BMC Infect Dis. 2012 Aug 1;12:173 DOI 10.1186/1471-2334-12-173 Authors Aucott JN, Seifter A, Rebman AW Abstract BACKGROUND: Lyme disease, a bacterial infection with the tick-borne spirochete Borrelia burgdorferi, can cause early and late manifestations. The category of probable Lyme disease was recently added to the CDC surveillance case definition to describe patients with serologic evidence of exposure and physician-diagnosed disease in the absence of objective signs. We present a retrospective case series of 13 untreated patients with persistent symptoms of greater than 12 weeks duration who meet these criteria and suggest a label of 'probable late Lyme disease' for this presentation. METHODS: The sample for this analysis draws from a retrospective chart review of consecutive, adult patients presenting between August 2002 and August 2007 to the author (JA), an infectious disease specialist. Patients were included in the analysis if their current illness had lasted greater than or equal to 12 weeks duration at the time of evaluation. RESULTS: Probable late Lyme patients with positive IgG serology but no history of previous physician-documented Lyme disease or appropriate Lyme treatment were found to represent 6% of our heterogeneous sample presenting with ? 12 weeks of symptom duration. Patients experienced a range of symptoms including fatigue, widespread pain, and cognitive complaints. Approximately one-third of this subset reported a patient-observed rash at illness onset, with a similar proportion having been exposed to non-recommended antibiotics or glucocorticosteroid treatment for their initial disease. A clinically significant response to antibiotics treatment was noted in the majority of patients with probable late Lyme disease, although post-treatment symptom recurrence was common. CONCLUSIONS: We suggest that patients with probable late Lyme disease share features with both confirmed late Lyme disease and post-treatment Lyme disease syndrome. Physicians should consider the recent inclusion of probable Lyme disease in the CDC Lyme disease surveillance criteria when evaluating patients, especially in patients with a history suggestive of misdiagnosed or inadequately treated early Lyme disease. Further studies are warranted to delineate later manifestations of Lyme disease and to quantify treatment benefit in this population. URL Previous https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-12-173 No Review Needed? Next

< Back Why is it so hard to find a Lyme doctor? Here are some reasons. LRC 21 Feb 2023 Previous Next

Video Library Here you can easily find all our video playlists from conferences and webinars in one place. Lyme disease: The new great imitator Lyme Disease - The New Great Imitator: D... Play Video Play Video 37:16 Lyme Resource Centre Diagnosing and Managing Lyme Disease in Primary Care Settings Dr. Anne Cruikshank discusses diagnosis and management of Lyme disease. Dr. Cruikshank is a GP from Oxfordshire, England, who was "Lyme Disease Champion" for the 2018-19 RCGP Spotlight Project on Lyme disease, and co-author of the RCGP Lyme Disease Toolkit. Part of the training course for healthcare professionals: "Lyme disease: The New Great Imitator" held via Zoom on 6th March 2021. Play Video Play Video 47:56 Lyme Resource Centre Lessons from a GP’s Personal Experience of Tick Bites and Lyme Disease Dr. Rachael Llewelyn describes her personal experience of Lyme disease as a patient and as a GP. Dr. Llewelyn is a GP from north Somerset, England, who was a member of the steering group of the 2018-19 RCGP Spotlight Project on Lyme Disease. Part of the training course for healthcare professionals: "Lyme Disease: The New Great Imitator" held via Zoom on 6th March 2021. Play Video Play Video 35:11 Lyme Resource Centre Questions Around Lyme Disease & the Challenge of Diagnosis and Treatment Dr. Zahra Husain discusses the challenges in Lyme disease diagnosis and treatment. Dr. Husain is a GP from London, England, who was a member of the steering group of the 2018-19 RCGP Spotlight Project on Lyme Disease, and co-author of the RCGP Lyme Disease Toolkit. Part of the training course for healthcare professionals: "Lyme Disease: The New Great Imitator" held via Zoom on 6th March 2021. Play Video Play Video 41:46 Lyme Resource Centre Chronic Infections With Lyme And Other Tickborne Pathogens Prof. Jack Lambert discusses what to do if early Lyme disease has been missed. Prof. Lambert is Professor of Medicine and Infectious Diseases at the Mater Misericordiae University Hospital, Rotunda Hospital, and UCD School of Medicine, Dublin. Part of the training course for healthcare professionals: "Lyme Disease: The New Great Imitator" held via Zoom on 6th March 2021. Play Video Play Video 12:39 Lyme Resource Centre Lyme Disease: Question and Answer Session Doctors answer questions on Lyme disease. Part of the training course for healthcare professionals: "Lyme Disease: The New Great Imitator" held via Zoom on 6th March 2021. Lyme disease: Delving deeper in to diagnosis & treatment of tick-bourne infections LYME DISEASE - Delving Deeper Into The D... Play Video Play Video 31:34 Lyme Resource Centre Dr Zahra Husain: Recognising Lyme disease - The Essentials (March 2022 Webinar Series) LYME DISEASE - Delving Deeper Into The Diagnosis & Treatment Of Tick-Borne Infections March 2022 Webinar Series Tuesday 15th March 2022 (19:00-20.15) Dr Zahra Husain: Recognising Lyme disease - The Essentials This series of webinars held over 3 evenings (via Zoom), focus on the key information needed by primary & secondary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of relevance to GPs, doctors and nurses in emergency and acute care settings, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Learning Outcomes: At the end of this series, attendees will be able to: - recognise the early signs and symptoms of Lyme disease ・ understand the importance of early and adequate treatment ・ access and use up to date guidelines on treatment of Lyme disease ・ discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment - recognise the potential signs and symptoms of neuroborreliosis - describe issues associated with diagnosing and treating Lyme disease in children. Course Director: Professor John (Jack) Lambert, Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre Play Video Play Video 26:14 Lyme Resource Centre Prof Jack Lambert : Case studies in diagnosing and treating Lyme disease (March 2022 Webinar Series) LYME DISEASE - Delving Deeper Into The Diagnosis & Treatment Of Tick-Borne Infections March 2022 Webinar Series Tuesday 15th March 2022 (19:00-20.15) Prof. Jack Lambert : Case studies in diagnosing and treating Lyme disease This series of webinars held over 3 evenings (via Zoom), focus on the key information needed by primary & secondary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of relevance to GPs, doctors and nurses in emergency and acute care settings, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Learning Outcomes: At the end of this series, attendees will be able to: - recognise the early signs and symptoms of Lyme disease ・ understand the importance of early and adequate treatment ・ access and use up to date guidelines on treatment of Lyme disease ・ discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment - recognise the potential signs and symptoms of neuroborreliosis - describe issues associated with diagnosing and treating Lyme disease in children. Course Director: Professor John (Jack) Lambert, Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre Play Video Play Video 24:22 Lyme Resource Centre Interactive Q&A Session with all speakers (2022-03-15) LYME DISEASE - Delving Deeper Into The Diagnosis & Treatment Of Tick-Borne Infections March 2022 Webinar Series Tuesday 15th March 2022 (19:00-20.15) Interactive Q&A Session with all speakers This series of webinars held over 3 evenings (via Zoom), focus on the key information needed by primary & secondary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of relevance to GPs, doctors and nurses in emergency and acute care settings, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Learning Outcomes: At the end of this series, attendees will be able to: - recognise the early signs and symptoms of Lyme disease ・ understand the importance of early and adequate treatment ・ access and use up to date guidelines on treatment of Lyme disease ・ discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment - recognise the potential signs and symptoms of neuroborreliosis - describe issues associated with diagnosing and treating Lyme disease in children. Course Director: Professor John (Jack) Lambert, Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre Play Video Play Video 23:32 Lyme Resource Centre Prof. Gareth Tudor Williams : Diagnosing and treating Lyme disease in children (23rd March 2022) LYME DISEASE - Delving Deeper Into The Diagnosis & Treatment Of Tick-Borne Infections March 2022 Webinar Series Wednesday 23rd March 2022 (19:00-20.15) Prof. Gareth Tudor Williams : Diagnosing and treating Lyme disease in children This series of webinars held over 3 evenings (via Zoom), focus on the key information needed by primary & secondary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of relevance to GPs, doctors and nurses in emergency and acute care settings, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Learning Outcomes: At the end of this series, attendees will be able to: - recognise the early signs and symptoms of Lyme disease ・ understand the importance of early and adequate treatment ・ access and use up to date guidelines on treatment of Lyme disease ・ discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment - recognise the potential signs and symptoms of neuroborreliosis - describe issues associated with diagnosing and treating Lyme disease in children. Course Director: Professor John (Jack) Lambert, Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre Play Video Play Video 28:46 Lyme Resource Centre Amelia Wildman : A teenager’s experience of Lyme disease (23rd March 2022) LYME DISEASE - Delving Deeper Into The Diagnosis & Treatment Of Tick-Borne Infections March 2022 Webinar Series Wednesday 23rd March 2022 (19:00-20.15) Amelia Wildman : A teenager’s experience of Lyme disease This series of webinars held over 3 evenings (via Zoom), focus on the key information needed by primary & secondary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of relevance to GPs, doctors and nurses in emergency and acute care settings, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Learning Outcomes: At the end of this series, attendees will be able to: - recognise the early signs and symptoms of Lyme disease ・ understand the importance of early and adequate treatment ・ access and use up to date guidelines on treatment of Lyme disease ・ discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment - recognise the potential signs and symptoms of neuroborreliosis - describe issues associated with diagnosing and treating Lyme disease in children. Course Director: Professor John (Jack) Lambert, Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre Play Video Play Video 16:41 Lyme Resource Centre Interactive Q&A Session with all speakers (2022-03-23) LYME DISEASE - Delving Deeper Into The Diagnosis & Treatment Of Tick-Borne Infections March 2022 Webinar Series Wednesday 23rd March 2022 (19:00-20.15) Interactive Q&A Session with all speakers This series of webinars held over 3 evenings (via Zoom), focus on the key information needed by primary & secondary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of relevance to GPs, doctors and nurses in emergency and acute care settings, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Learning Outcomes: At the end of this series, attendees will be able to: - recognise the early signs and symptoms of Lyme disease ・ understand the importance of early and adequate treatment ・ access and use up to date guidelines on treatment of Lyme disease ・ discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment - recognise the potential signs and symptoms of neuroborreliosis - describe issues associated with diagnosing and treating Lyme disease in children. Course Director: Professor John (Jack) Lambert, Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre Play Video Play Video 25:49 Lyme Resource Centre Dr Anne Cruikshank : Neuroborreliosis - Recognising the neurological and psychiatric manifestations LYME DISEASE - Delving Deeper Into The Diagnosis & Treatment Of Tick-Borne Infections March 2022 Webinar Series Tuesday 29th March 2022 (19:00-20.15) Dr. Anne Cruikshank - Neuroborreliosis - Recognising the neurological and psychiatric manifestations of Lyme disease This series of webinars held over 3 evenings (via Zoom), focus on the key information needed by primary & secondary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of relevance to GPs, doctors and nurses in emergency and acute care settings, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Learning Outcomes: At the end of this series, attendees will be able to: - recognise the early signs and symptoms of Lyme disease ・ understand the importance of early and adequate treatment ・ access and use up to date guidelines on treatment of Lyme disease ・ discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment - recognise the potential signs and symptoms of neuroborreliosis - describe issues associated with diagnosing and treating Lyme disease in children. Course Director: Professor John (Jack) Lambert, Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre Play Video Play Video 25:14 Lyme Resource Centre Prof. Jack Lambert : Case studies - An approach to managing neuroborreliosis (29th March 2022) LYME DISEASE - Delving Deeper Into The Diagnosis & Treatment Of Tick-Borne Infections March 2022 Webinar Series Tuesday 29th March 2022 (19:00-20.15) Prof. Jack Lambert - Case studies - an Infectious Disease consultant’s approach to managing neuroborreliosis This series of webinars held over 3 evenings (via Zoom), focus on the key information needed by primary & secondary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of relevance to GPs, doctors and nurses in emergency and acute care settings, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Learning Outcomes: At the end of this series, attendees will be able to: - recognise the early signs and symptoms of Lyme disease ・ understand the importance of early and adequate treatment ・ access and use up to date guidelines on treatment of Lyme disease ・ discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment - recognise the potential signs and symptoms of neuroborreliosis - describe issues associated with diagnosing and treating Lyme disease in children. Course Director: Professor John (Jack) Lambert, Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre Lyme disease: Byte Size Sessions LYME DISEASE - Byte Size Sessions Play Video Play Video 29:57 Lyme Resource Centre Dr Anne Cruikshank: Diagnosing and managing Lyme disease in Primary Care settings LYME DISEASE - THE NEW GREAT IMITATOR Diagnosis & Treatment of Tick-Borne Infections in Primary Care. Wednesday 8th September 2021 What primary care clinicians need to know about Lyme disease? This series of complementary webinars held over 3 evenings (via Zoom), focus on challenges faced by primary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of particular relevance to GPs, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Zoom meeting details will be provided upon registration. Learning Outcomes: At the end of this series, attendees will be able to: - outline the importance of early diagnosis and appropriate treatment in the prevention of persistent symptoms - confidently manage tick bites and treat early Lyme disease - access and use up to date guidelines on the treatment of Lyme disease - discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment. Course Director: Professor John (Jack) Lambert Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre Play Video Play Video 29:09 Lyme Resource Centre Dr Rachael Llewelyn: Lessons from a GP’s personal experience of tick bites and Lyme disease LYME DISEASE - THE NEW GREAT IMITATOR Diagnosis & Treatment of Tick-Borne Infections in Primary Care. Wednesday 8th September 2021 What primary care clinicians need to know about Lyme disease? This series of complementary webinars held over 3 evenings (via Zoom), focus on challenges faced by primary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of particular relevance to GPs, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Zoom meeting details will be provided upon registration. Learning Outcomes: At the end of this series, attendees will be able to: - outline the importance of early diagnosis and appropriate treatment in the prevention of persistent symptoms - confidently manage tick bites and treat early Lyme disease - access and use up to date guidelines on the treatment of Lyme disease - discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment. Course Director: Professor John (Jack) Lambert Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre Play Video Play Video 21:49 Lyme Resource Centre Session Q&A: 8th September 2021 LYME DISEASE - THE NEW GREAT IMITATOR Diagnosis & Treatment of Tick-Borne Infections in Primary Care What primary care clinicians need to know about Lyme disease? This series of complementary webinars held over 3 evenings (via Zoom), focus on challenges faced by primary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of particular relevance to GPs, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Zoom meeting details will be provided upon registration. Learning Outcomes: At the end of this series, attendees will be able to: - outline the importance of early diagnosis and appropriate treatment in the prevention of persistent symptoms - confidently manage tick bites and treat early Lyme disease - access and use up to date guidelines on the treatment of Lyme disease - discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment. Course Director: Professor John (Jack) Lambert Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre Play Video Play Video 33:27 Lyme Resource Centre Dr Zahra Husain: Lyme disease the challenge of diagnosis and treatment LYME DISEASE - THE NEW GREAT IMITATOR Diagnosis & Treatment of Tick-Borne Infections in Primary Care. Wednesday 22nd September 2021 The challenges in diagnosis and treatment of Lyme disease This series of complementary webinars held over 3 evenings (via Zoom), focus on challenges faced by primary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of particular relevance to GPs, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Zoom meeting details will be provided upon registration. Learning Outcomes: At the end of this series, attendees will be able to: - outline the importance of early diagnosis and appropriate treatment in the prevention of persistent symptoms - confidently manage tick bites and treat early Lyme disease - access and use up to date guidelines on the treatment of Lyme disease - discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment. Course Director: Professor John (Jack) Lambert Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre Play Video Play Video 30:23 Lyme Resource Centre Prof Jack Lambert: Diagnosis and management of late disseminated Lyme disease LYME DISEASE - THE NEW GREAT IMITATOR Diagnosis & Treatment of Tick-Borne Infections in Primary Care. Wednesday 22nd September 2021 The challenges in diagnosis and treatment of Lyme disease. This series of complementary webinars held over 3 evenings (via Zoom), focus on challenges faced by primary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of particular relevance to GPs, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Zoom meeting details will be provided upon registration. Learning Outcomes: At the end of this series, attendees will be able to: - outline the importance of early diagnosis and appropriate treatment in the prevention of persistent symptoms - confidently manage tick bites and treat early Lyme disease - access and use up to date guidelines on the treatment of Lyme disease - discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment. Course Director: Professor John (Jack) Lambert Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre Play Video Play Video 20:58 Lyme Resource Centre Session Q&A: 22nd September 2021 LYME DISEASE - THE NEW GREAT IMITATOR Diagnosis & Treatment of Tick-Borne Infections in Primary Care The challenges in diagnosis and treatment of Lyme disease. This series of complementary webinars held over 3 evenings (via Zoom), focus on challenges faced by primary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of particular relevance to GPs, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Zoom meeting details will be provided upon registration. Learning Outcomes: At the end of this series, attendees will be able to: - outline the importance of early diagnosis and appropriate treatment in the prevention of persistent symptoms - confidently manage tick bites and treat early Lyme disease - access and use up to date guidelines on the treatment of Lyme disease - discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment. Course Director: Professor John (Jack) Lambert Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre Play Video Play Video 29:27 Lyme Resource Centre Prof Jack Lambert: Persistent infections with Lyme and other tick borne diseases LYME DISEASE - THE NEW GREAT IMITATOR Diagnosis & Treatment of Tick-Borne Infections in Primary Care Wednesday 29th September 2021 Lyme disease – when your patient doesn’t get better. This series of complementary webinars held over 3 evenings (via Zoom), focus on challenges faced by primary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of particular relevance to GPs, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Zoom meeting details will be provided upon registration. Learning Outcomes: At the end of this series, attendees will be able to: - outline the importance of early diagnosis and appropriate treatment in the prevention of persistent symptoms - confidently manage tick bites and treat early Lyme disease - access and use up to date guidelines on the treatment of Lyme disease - discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment. Course Director: Professor John (Jack) Lambert Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre Play Video Play Video 30:17 Lyme Resource Centre Monica Wilde: The role of integrative medicine in the management of persistent Lyme disease symptoms LYME DISEASE - THE NEW GREAT IMITATOR Diagnosis & Treatment of Tick-Borne Infections in Primary Care Wednesday 29th September 2021 Lyme disease – when your patient doesn’t get better. This series of complementary webinars held over 3 evenings (via Zoom), focus on challenges faced by primary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of particular relevance to GPs, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Zoom meeting details will be provided upon registration. Learning Outcomes: At the end of this series, attendees will be able to: - outline the importance of early diagnosis and appropriate treatment in the prevention of persistent symptoms - confidently manage tick bites and treat early Lyme disease - access and use up to date guidelines on the treatment of Lyme disease - discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment. Course Director: Professor John (Jack) Lambert Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre LYME DISEASE - THE NEW GREAT IMITATOR Diagnosis & Treatment of Tick-Borne Infections in Primary CarE LYME DISEASE - THE NEW GREAT IMITATOR Di... Play Video Play Video 01:43:50 Lyme Resource Centre Diagnosis & Treatment of Tick-Borne Infections in Primary Care: Session from 08/09/2021 LYME DISEASE - THE NEW GREAT IMITATOR Diagnosis & Treatment of Tick-Borne Infections in Primary Care. This series of complementary webinars held over 3 evenings (via Zoom), focus on challenges faced by primary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of particular relevance to GPs, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Zoom meeting details will be provided upon registration. Learning Outcomes: At the end of this series, attendees will be able to: - outline the importance of early diagnosis and appropriate treatment in the prevention of persistent symptoms - confidently manage tick bites and treat early Lyme disease - access and use up to date guidelines on the treatment of Lyme disease - discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment. Course Director: Professor John (Jack) Lambert Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre. Play Video Play Video 01:40:34 Lyme Resource Centre Diagnosis & Treatment of Tick-Borne Infections in Primary Care: Session from 22/09/2021 LYME DISEASE - THE NEW GREAT IMITATOR Diagnosis & Treatment of Tick-Borne Infections in Primary Care. This series of complementary webinars held over 3 evenings (via Zoom), focus on challenges faced by primary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of particular relevance to GPs, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Zoom meeting details will be provided upon registration. Learning Outcomes: At the end of this series, attendees will be able to: - outline the importance of early diagnosis and appropriate treatment in the prevention of persistent symptoms - confidently manage tick bites and treat early Lyme disease - access and use up to date guidelines on the treatment of Lyme disease - discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment. Course Director: Professor John (Jack) Lambert Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre. Play Video Play Video 01:37:52 Lyme Resource Centre Diagnosis & Treatment of Tick-Borne Infections in Primary Care: Session from 29/09/2021 LYME DISEASE - THE NEW GREAT IMITATOR Diagnosis & Treatment of Tick-Borne Infections in Primary Care. This series of complementary webinars held over 3 evenings (via Zoom), focus on challenges faced by primary care clinicians in relation to the diagnosis and treatment of Lyme disease. These learning events are open to health professionals and will be of particular relevance to GPs, practice nurses, pharmacists, paramedics and those working in minor injury units across all parts of the UK and Ireland. Zoom meeting details will be provided upon registration. Learning Outcomes: At the end of this series, attendees will be able to: - outline the importance of early diagnosis and appropriate treatment in the prevention of persistent symptoms - confidently manage tick bites and treat early Lyme disease - access and use up to date guidelines on the treatment of Lyme disease - discuss the recognised scientific uncertainties and the need for further research in relation to both diagnosis and treatment. Course Director: Professor John (Jack) Lambert Consultant in Infectious Diseases, Mater Misericordiae University Hospital/University College Dublin, Ireland. Lead Trustee of Lyme Resource Centre. LYME DISEASE: Small bites for GPS Lyme Disease - Small Bites for GPs Play Video Play Video 08:17 Lyme Resource Centre Lyme Disease - Small Bites for GPs 1: What is Lyme disease and where does it come from? Prof. Jack Lambert is a Professor in Medicine and Infectious Diseases at Mater Misericordiae University Hospital and UCD School of Medicine, Dublin, with both extensive clinical and research expertise. As part of our series "Lyme Disease - Small Bites for GPs", he introduces Lyme disease and its origins. Play Video Play Video 03:15 Lyme Resource Centre Lyme Disease - Small Bites for GPs 2: Why can’t we expect to eradicate Borrelia with antibiotics? Prof. Jack Lambert is a Professor in Medicine and Infectious Diseases at Mater Misericordiae University Hospital and UCD School of Medicine, Dublin, with both extensive clinical and research expertise. As part of our series "Lyme Disease - Small Bites for GPs", he discusses why we can’t always just treat Borrelia with an antibiotic and expect it to be eradicated. Play Video Play Video 10:57 Lyme Resource Centre Lyme Disease - Small Bites for GPs 3: How do you test for Lyme disease? Prof. Jack Lambert is a Professor in Medicine and Infectious Diseases at Mater Misericordiae University Hospital and UCD School of Medicine, Dublin, with both extensive clinical and research expertise. As part of our series "Lyme Disease - Small Bites for GPs", he discusses Lyme disease testing. Play Video Play Video 05:17 Lyme Resource Centre Lyme Disease - Small Bites for GPs 4: What is the infection rate from a tick bite? Prof. Jack Lambert is a Professor in Medicine and Infectious Diseases at Mater Misericordiae University Hospital and UCD School of Medicine, Dublin, with both extensive clinical and research expertise. As part of our series "Lyme Disease - Small Bites for GPs", he discusses transmission of infection to humans. Play Video Play Video 02:14 Lyme Resource Centre Lyme Disease - Small Bites for GPs 5: Can you test ticks removed to see if they carry bacteria? Prof. Jack Lambert is a Professor in Medicine and Infectious Diseases at Mater Misericordiae University Hospital and UCD School of Medicine, Dublin, with both extensive clinical and research expertise. As part of our series "Lyme Disease - Small Bites for GPs", he discusses tick testing. Play Video Play Video 06:23 Lyme Resource Centre Lyme Disease - Small Bites for GPs 6: Where and when are you most likely to contract Lyme disease? Prof. Jack Lambert is a Professor in Medicine and Infectious Diseases at Mater Misericordiae University Hospital and UCD School of Medicine, Dublin, with both extensive clinical and research expertise. As part of our series "Lyme Disease - Small Bites for GPs", he discusses the likelihood of contracting Lyme disease. Play Video Play Video 07:54 Lyme Resource Centre Lyme Disease - Small Bites for GPs 7: Is incidence of Lyme disease and tick-borne infection rising? Prof. Jack Lambert is a Professor in Medicine and Infectious Diseases at Mater Misericordiae University Hospital and UCD School of Medicine, Dublin, with both extensive clinical and research expertise. As part of our series "Lyme Disease - Small Bites for GPs", he discusses the incidence of Lyme disease and tick borne infections. Play Video Play Video 11:10 Lyme Resource Centre Lyme Disease - Small Bites for GPs 8: Why is Lyme disease such a controversial topic? Prof. Jack Lambert is a Professor in Medicine and Infectious Diseases at Mater Misericordiae University Hospital and UCD School of Medicine, Dublin, with both extensive clinical and research expertise. As part of our series "Lyme Disease - Small Bites for GPs", he discusses the controversy of Lyme disease and the challenges of diagnosis and treatment. 2nd european crypto-infections conference 2nd European Crypto-Infections Conferenc... Play Video Play Video 09:20 Lyme Resource Centre Introduction Prof. Jack Lambert, 2nd European Crypto-Infections Conference 26th-27th September 2020, via Zoom Play Video Play Video 28:04 Lyme Resource Centre One Health: Forming collaborations that transcend disciplinary boundaries Dr. Cheryl Stroud, 2nd European Crypto-Infections Conference 26th-27th September 2020, via Zoom Play Video Play Video 18:24 Lyme Resource Centre PCR for crypto-infections diagnosis in patients with PTLDS: Comparison of matrices Prof. Christian Perronne, 2nd European Crypto-Infections Conference 26th-27th September 2020, via Zoom Play Video Play Video 52:37 Lyme Resource Centre Clinical spectrum of persistent Bartonella infection and considerations in Diagnosis and Treatment Dr B Robert Mozayeni, 2nd European Crypto-Infections Conference 26th-27th September 2020, via Zoom Play Video Play Video 30:32 Lyme Resource Centre Hiding in the body: metamorphoses of Lyme disease spirochetes Dr. Natasha Rudenko, 2nd European Crypto-Infections Conference 26th-27th September 2020, via Zoom Play Video Play Video 15:57 Lyme Resource Centre Late Lyme carditis Dr. Vett Lloyd, 2nd European Crypto-Infections Conference 26th-27th September 2020, via Zoom Play Video Play Video 11:39 Lyme Resource Centre Borrelia bissettii in Canada Samantha Bishop, 2nd European Crypto-Infections Conference 26th-27th September 2020, via Zoom Play Video Play Video 18:28 Lyme Resource Centre Tissue distribution of B. burgdorferi and B. miyamotoi in wildlife Christopher Zinck and Dr. Vett Lloyd, 2nd European Crypto-Infections Conference 26th-27th September 2020, via Zoom Lyme disease: "the new great imitator" - training course for healthcare professionals "Lyme Disease: The New Great Imitator": ... Play Video Play Video 37:16 Lyme Resource Centre Diagnosing and Managing Lyme Disease in Primary Care Settings Dr. Anne Cruikshank discusses diagnosis and management of Lyme disease. Dr. Cruikshank is a GP from Oxfordshire, England, who was "Lyme Disease Champion" for the 2018-19 RCGP Spotlight Project on Lyme disease, and co-author of the RCGP Lyme Disease Toolkit. Part of the training course for healthcare professionals: "Lyme disease: The New Great Imitator" held via Zoom on 6th March 2021. Play Video Play Video 47:56 Lyme Resource Centre Lessons from a GP’s Personal Experience of Tick Bites and Lyme Disease Dr. Rachael Llewelyn describes her personal experience of Lyme disease as a patient and as a GP. Dr. Llewelyn is a GP from north Somerset, England, who was a member of the steering group of the 2018-19 RCGP Spotlight Project on Lyme Disease. Part of the training course for healthcare professionals: "Lyme Disease: The New Great Imitator" held via Zoom on 6th March 2021. Play Video Play Video 35:11 Lyme Resource Centre Questions Around Lyme Disease & the Challenge of Diagnosis and Treatment Dr. Zahra Husain discusses the challenges in Lyme disease diagnosis and treatment. Dr. Husain is a GP from London, England, who was a member of the steering group of the 2018-19 RCGP Spotlight Project on Lyme Disease, and co-author of the RCGP Lyme Disease Toolkit. Part of the training course for healthcare professionals: "Lyme Disease: The New Great Imitator" held via Zoom on 6th March 2021. Play Video Play Video 41:46 Lyme Resource Centre Chronic Infections With Lyme And Other Tickborne Pathogens Prof. Jack Lambert discusses what to do if early Lyme disease has been missed. Prof. Lambert is Professor of Medicine and Infectious Diseases at the Mater Misericordiae University Hospital, Rotunda Hospital, and UCD School of Medicine, Dublin. Part of the training course for healthcare professionals: "Lyme Disease: The New Great Imitator" held via Zoom on 6th March 2021. Play Video Play Video 12:39 Lyme Resource Centre Lyme Disease: Question and Answer Session Doctors answer questions on Lyme disease. Part of the training course for healthcare professionals: "Lyme Disease: The New Great Imitator" held via Zoom on 6th March 2021. 1st european crypto-infections conference 1st European Crypto-Infections Conferenc... Play Video Play Video 36:42 Lyme Resource Centre Cryptic Infections in Pregnancy - Dr. John (Jack) Lambert 1st European Crypto-Infections Conference, 31 May - 1 June 2019, Dublin Play Video Play Video 36:50 Lyme Resource Centre The Value of Serological Assays for the Diagnosis of Crypto-Infections - Michael Cook 1st European Crypto-Infections Conference, 31 May - 1 June 2019, Dublin Play Video Play Video 36:28 Lyme Resource Centre Tick-borne Disease Diagnostics: The Good the Bad and the Ugly - Dr. Leona Gilbert 1st European Crypto-Infections Conference, 31 May - 1 June 2019, Dublin Play Video Play Video 41:28 Lyme Resource Centre Molecular biology and ecology of ticks and tick-borne pathogens - Dr. Natasha Rudenko 1st European Crypto-Infections Conference, 31 May - 1 June 2019, Dublin Play Video Play Video 49:56 Lyme Resource Centre Antigen Based Diagnostics: the value of PCR in crypto-infection diagnosis - Prof. Christian Perronne 1st European Crypto-Infections Conference, 31 May - 1 June 2019, Dublin Play Video Play Video 31:31 Lyme Resource Centre Patient care in Québec and recent initiatives in Canada - Dr. Amir Khadir 1st European Crypto-infections Conference, 31 May - 1 June 2019, Dublin Play Video Play Video 53:08 Lyme Resource Centre Developing Effective Treatment of Persistent Lyme Disease: Where are we now? - Prof. Ying Zhang 1st European Crypto-infections Conference, 31 May-1 June 2019, Dublin Play Video Play Video 21:37 Lyme Resource Centre Trials of Artemisia tea to treat malaria and schistosomiasis - Dr. Lucile Cornet-Vernet 1st European Crypto-infections Conference, 31 May - 1 June 2019, Dublin

< Back to Research Top Published Date 07/08/2014 Comparative analysis of the infectivity rate of both Borelia burgdorferi and Anaplasma phagocytophilum in humans and dogs in a New Jersey community Journal Infection and Drug Resistance Citation Infect Drug Resist. 2014 Aug 7;7:199-201. DOI 10.2147/IDR.S68742 Authors Gaito A, Gjivoje V, Lutz S, Baxtr B Abstract Ticks are important vectors of disease and transmit an extensive array of bacterial, viral and protozoan diseases to both humans and dogs within a community. Borrelia burgdorferi, the causative agent of Lyme disease, has been extensively studied within both the human and veterinary population. Anaplasma phagocytophilum, an intracellular rickettsial pathogen also transmitted by ixodid ticks, has emerged as an important zoonotic infection with significant veterinary and medical implications, and is responsible for both canine granulocytic anaplasmosis and human granulocytic anaplasmosis. Multiple surveys exist in the international literature referencing infectivity rates of both of these diseases separately in both the dog and human populations. This is the first study to simultaneously examine the infectivity rate of both anaplasmosis and Lyme disease in humans and dogs in a community endemic for tick-borne diseases. URL Previous https://www.ncbi.nlm.nih.gov/pubmed/25143748 No Review Needed? Next

< Back to Research Top Published Date 10/02/2016 Eradication of Biofilm-Like Microcolony Structures of Borrelia burgdorferi by Daunomycin and Daptomycin but not Mitomycin C in Combination with Doxycycline and Cefuroxime Journal Frontiers in Microbiology Citation Front Microbiol. 2016 Feb 10;7:62 DOI 10.3389/fmicb.2016.00062 Authors Feng J, Weitner M, Shi W, Zhang S, Zhang Y Abstract Lyme disease, caused by Borrelia burgdorferi, is the most common vector-borne disease in the United States and Europe. While the majority of Lyme disease patients can resolve their symptoms if treated promptly, 10-20% of patients suffer from prolonged symptoms called post-treatment Lyme disease syndrome (PTLDS). Although the cause for PTLDS is unclear, one possibility is the presence of bacterial persisters not effectively cleared by the current Lyme antibiotics. Recent studies identified several drug candidates including daptomycin, daunomycin, doxorubicin, and mitomycin C that had good activity against B. burgdorferi persisters. However, their relative activities against B. burgdorferipersisters have not been evaluated under the same conditions. In this study, we tested the anti-persister activities of these drugs against both 7-day and 15-day old stationary phase cultures of B. burgdorferi individually as well as in combination with Lyme antibiotics doxycycline and cefuroxime (Ceftin). Our findings demonstrate daunomycin and daptomycin were more active than mitomycin C in single drug comparison at 10 and 20 μM, as well as in drug combinations with doxycycline and cefuroxime. In addition, daunomycin was more active than doxorubicin which correlated with their ability to stain and accumulate in B. burgdorferi. The two drug combination of doxycycline and cefuroxime was unable to eradicate biofilm-like microcolonies of B. burgdorferi persisters. However, the addition of either daunomycin or daptomycin to the doxycycline + cefuroxime combination completely eradicated the biofilm-like structures and produced no visible bacterial regrowth after 7 and 21 days, while the addition of doxorubicin was unable to prevent regrowth at either 7 or 21 day subculture. Mitomycin C in combination with doxycycline and cefuroxime caused no regrowth at 7 days but visible spirochetal regrowth occurred after 21 day subculture. Furthermore, we found that cefuroxime (Ceftin), the third commonly used and most active antibiotic to treat Lyme disease, could replace cefoperazone (a drug no longer available in the US) in the daptomycin + doxycycline combination with complete eradication of the biofilm-like structures as shown by lack of any regrowth in subcultures. Our findings may have implications for improved treatment of Lyme disease. URL Previous https://www.frontiersin.org/articles/10.3389/fmicb.2016.00062/full No Review Needed? Next

< Back to Research Top Published Date 01/05/2012 Long term antibiotic therapy may be an effective treatment for children co-morbid with Lyme disease and Autism Spectrum Disorder Journal Medical Hypotheses Citation Med Hypotheses . 2012 May;78(5):606-15 DOI 10.1016/j.mehy.2012.01.037 Authors Kuhn M , Grave S, Bransfield R, Harris S Abstract Patients diagnosed with Lyme disease share many of the same physical manifestations as those diagnosed with an Autism Spectrum Disorder (ASD). In this study four male children (ages 26?55 months) who have an ASD diagnosis and one male child (age 18 months) who displayed behaviors consistent with an ASD, were assessed using the SCERTS Assessment Process Observation (SAP-O) form. The SAP-O meets state and federal requirements for providing a compreh URL Previous https://pubmed.ncbi.nlm.nih.gov/22361005/ No Review Needed? Next

CRYPTO-INFECTIONS CONFERENCE 2023 LYME DISEASE & OTHER HIDDEN INFECTIONS: MICROBIAL PERSISTENCE (HYBRID ATTENDANCE IN PERSON OR ONLINE) About the event HYBRID ATTENDANCE IN PERSON OR ONLINE Join Zoom Meeting links will be provided before the event. To book, please see the details below. The Third international ‘CryptoConference’ will be held in Dublin Ireland June 17th to 18th 2023. ‘Crypto’ refers to occult infections which are hard to diagnose and hard to treat. The theme of the third conference is ‘microbial persistence’, which is the way that these occult infections evade the immune system and evade routine diagnostic techniques. We have invited a range of clinicians and basic scientists from the USA, Canada, and throughout the European Union, to spend two days in Dublin. The topics to be addressed include Borrelia, Bartonella, Babesia, and a range of other microbial pathogens. Lectures will be provided that will appeal to primary care doctors (general practitioners) on the subject of Lyme and Long COVID, as well as more basic science lectures that will appeal to bench researchers as well as clinicians. This event is recognised for CPD. For issues or queries about the conference, please contact the conference organiser Gordana Avramovic gavramovic@mater.ie Bookings Closed Meeting Agenda See More Speaker Biographies See More MEETING AGENDA SATURDAY 17th June 2023 CHAIRS: Prof John (Jack) Lambert & Christian Perronne Time Title Speaker 08:30 Introduction Prof John (Jack) Lambert 08:40 An Overview of Persistent Infections Prof Christian Perronne 09:30 A One Health approach to understanding and preventing Zoonotic infections Prof Gerald Barry 10:00 Lyme Persistence Dr Monica Embers 11:00 Coffee break 11:20 From bedside to bench- A clinicians journey in caring for patients with tickborne disease Dr Chris Green 12:00 Persistent Bartonella infection Dr B Robert Mozayeni 13:00 LUNCH & POSTER DISPLAY 14:00 Persistence of Lyme Disease Spirochetes- an Unsolved Problem Dr Natasha Rudenko 14:30 SIX ABSTRACTS- (10 minutes each- 10 minutes for questions) (See notes below) 15:40 Persistent Babesia Infection Dr Adam Birkenheuer 16:40 Why collaborate with patients? Christele Dumas Gonnet 17:10 Alzheimer Induced By Microbial Persistence Mikolaj Hurla 17:40 End of First day - Drinks & Reception SIX ABSTRACTS Prof Dominique SALMON, Maladies Infectieuses, Université de Paris Cite, France Dr Ritti Soncco, Social and Medical Anthropology, University of Edinburgh Mickaël GUERIN, Ph.D Student,CNRS Université de Technologie de Compiègne, Sorbonne Université Prof Vett Lloyd, Mt. Allison University , New Brunswick, Canada Dr Amir Khadir, Hôpital Le Gardeur, Terrebonne, Québec, Canada Abbie Thoma, Medical student, Mater Misericordiae University Hospital, Dublin, Ireland ABSTRACT QUESTIONS (10 minutes) MEETING AGENDA Sunday 18th June 2023 CHAIRS: Prof Christian Perronne, Prof Gerald Barry Time Title Speaker 09:00 Introduction 09:15 Long COVID Dr John (Jack) Lambert 10:15 Neuropsychiatric Manifestations of Tick-borne Infections Dr Bob Bransfield 11:15 Coffee break 11:45 The Importance Of Chronic Infections In Chronic Disease And The Potential Role Of Mitochondria Prof Karl Morten 12:15 TWO ABSTRACTS (10 minute presentations and 10 minutes for questions) (See notes below) 12:35 From Bench to the Sandbox: Sparking Curiosity to Ignite Scientific Discovery and Social Innovation Laura Lott, MBA 13:15 Round Table & Conclusions Prof Christian Perronne, Prof John Lambert & Dr Chris Green 13:45 End of conference TWO ABSTRACTS Elizabeth Lee-Lewandrowski, Ph.D. MP, Assistant Professor, Harvard Medical School, Massachusetts General Hospital, Boston Massachusetts, USA Tanja Mijatovic, PhD, CSO & Lab Manager, R.E.D. Laboratories ABSTRACT QUESTIONS (10 minutes) ACCEPTED POSTERS Evaluation of the Rapid Quidel Sofia 2 Lyme immunoassay as a First-Tier Test in a Two-Tier Testing Algorithm for Lyme Disease. Comparison to the Zeus ELISA Borrelia VisE1/pepC10 IgG/IgM assay. Lewandrowski E.L.¹,², Lewandrowski K.¹,², Branda J.1,2, Turbett S.¹,² (1) Department of Pathology, Division of Clinical Laboratories and Molecular Medicine, Massachusetts General Hospital (2) Harvard Medical School . Lyme Diagnosis: Contribution of Clinical Data Analysis by Machine Learning Shawky M. ¹, Guerin M.², Maffucci I.², Octave S², Avalie B.², Padiolleau-Lefevre S.² COSTECH laboratory, Universite de technologie de Compiegne, France. GEC laboratory. Polyclinique Saint-Come, Compiegne, France. Developing A Blood Cell-Based Diagnostic Test For Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Peripheral Blood Mononuclear Cells. Xu J¹, Lodge T², Kingdon C³, Strong J.W.L.², Maclennan J.⁴, Lacerda E.³, Kujawski S⁵, Zalewski P.⁵,⁶, Huang W.E¹, Morten K.J.² (1)Department of Engineering Science, University of Oxford. (2) Nuffield Department of Women’s and Reproductive Health, University of Oxford. (3) Faculty of Infectious Diseases, London School of Hygiene and Tropical Medicine. (4) Soft Cell Biological Research. (5) Department of Exercise Physiology and Functional Anatomy. Nicolaus Copernicus University in Torun. (6) Department of Experimental and Clinical Physiology. Warsaw Medical University. * A Decrease In CD57+ NK Cells Is Demonstrated In Patients Positive For Tick-Borne Infections. Thoma A¹, Avramovic G², Rajput-Ray M³ Gilbert L⁴, Madigan A², Lambert J¹,² (1) University College Dublin, Ireland. (2) Mater Misericordiae University Hospital, Dublin Ireland. (3) Curaidh Clinic, Dundee, Scotland, UK. (4) Te?ted Oy, Jyväskylä, Finland A Greater Severity Of Fatigue Is Demonstrated In Weakly Antibody-Positive Patients In A Tick-Borne Infection (TBI) Cohort. Thoma A¹, Avramovic G², Rajput-Ray M³, Gilbert L⁴, Madigan A², Lambert J¹,² (1) University College Dublin, Ireland. (2) Mater Misericordiae University Hospital, Dublin Ireland. (3) Curaidh Clinic, Dundee, Scotland, UK. (4) Te?ted Oy, Jyväskylä, Finland SPEAKERS’ BIOGRAPHIES Prof Jack (John) Lambert Consultant Infectious Diseases, Mater Misericordiae University Hospital/ University College Dublin, Ireland Dr John lambert is is a consultant in Infectious diseases and genitourinary medicine, and has been practicing in Dublin Ireland as a consultant in the Mater and Rotunda Maternity hospitals, with teaching appointment at UCD School of Medicine and Medical Science. He is director of the National Isolation Unit for Highly Infectious Diseases at the Mater Misericordiae University Hospital and a member of the National Viral Hemorrhagic Fever Committee of the HSE. He has also been involved in the Sexual Health Strategy group in Ireland and teaching GP in Ireland on the subject of STDs. He has presented widely in the field of Lyme and co infections in the last 3 years through EU and USA conferences supported by the International Lyme and Associated Diseases Society (ILADS). Prof Christian Perronne Former Professor of Infectious and Tropical Diseases at the University of Versailles-St Quentin (UVSQ), France Christian Perronne, MD, PhD, qualified in Internal medicine, is Professor of Infectious and Tropical Diseases. He retired in March 2022 from the University of Versailles-Paris Saclay, France. From 1994 to 2020, he was chief of a Department of medicine at the Raymond Poincaré University Hospital in Garches, Greater Paris University Hospitals group. He had major responsibilities within several institutions: Pasteur institute in Paris (vice-director of the national tuberculosis reference center), French College of Professors of Infectious and Tropical Diseases (chairman), French National Technical Advisory Group of Experts on Immunisation (chairman), French Drug Agency (chairman of several working groups making evidence based recommendations), Superior Council for Public Hygiene of France (Chairman), French High Council for Public Health (Chairman of the Communicable diseases commission), INSERM, National Council of Universities (Chairman for infectious and tropical diseases), European Advisory Group of Experts on Immunisation at the World Health Organization (vice-chairman). He was principal investigator of several major clinical trials. He is author or co-author of more than 300 scientific publications in peer-reviewed journals. Since 1994, Christian Perronne is involved in the management of chronic Lyme and associated diseases. He is author of a book “La vérité sur la maladie de Lyme” (in French) (“The truth about Lyme disease”), Odile Jacob publisher, Paris, which will be published in English in May 2020 (“Crypto-infection, the truth about Lyme disease and other hidden infections”), Hammersmith publisher, London, Dublin. Dr. Gerald Barry Assistant Professor of Virology in University College Dublin Gerald is chair of the Irish Division of the Microbiology Society, and a member of the Irish Government's Environmental Protection Agency GMO advisory committee. Dr Barry has worked on viruses that infect both animals and / or humans for over 15 years and his group's work mainly focuses on how viruses interact with their hosts and what, on a molecular level, determines a viruses ability to jump species and become zoonotic. Dr. Barry's group is also engaged in surveillance work, identifying viruses in animals and insects that have zoonotic potential. During the pandemic Dr. Barry engaged in research specific to COVID-19 and contributed to reports on aspects of SARS-CoV-2 diagnostics and prevention of infection in the workplace. Previously, Dr. Barry has worked with colleagues in the UK and Europe to understand ticks, how they carry and transmit infectious agents and specifically tick - borne infections such as Borrelia Burgdorferi, the causative agent of Lyme Disease. Dr. Monica Embers Associate Professor in the Division of Immunology and the Director of Vector-borne Disease Research at the Tulane National Primate Research Center, USA. Dr. Embers is currently an Associate Professor in the Division of Immunology and the Director of Vector-borne Disease Research at the Tulane National Primate Research Center. Her research program regarding Lyme disease and its infectious cause Borrelia burgdorferi specializes in animal models. The research is centered around three major efforts: (1) identifying treatments that can eradicate B. burgdorferi infection; (2) detection of persistent Lyme disease spirochetes in human (autopsy) tissues; and (3) immunodiagnosis for B. burgdorferi infection and cure. By transmitting Lyme disease to mice and nonhuman primates by tick, and studying the natural course of infection, her group aims to attain a better understanding of the clinical quandaries of human Lyme disease, including effective diagnosis and treatment. Due to the many similarities between Bartonellosis and Lyme disease, her team has begun to develop research models for Bartonella infection. The goals of Bartonella research involve developing improved treatment strategies, understanding the pathophysiology of co-infection, and interrogating tick vector transmission of these pathogens. Dr Christine Green, MD Board Certified Family Physician, San Francisco, USA Dr. Christine Green is a board certified family physician practicing in the San Francisco Bay area for over 35 years. Returning patients to excellent health often requires “medical sleuthing.” Understanding the physiology of the body and its interaction with infection (pathophysiology) led Dr. Green to her expertise in chronic vector-borne diseases, including persistent (chronic) tickborne diseases. The CDC notes that there are over 500,000 new cases of Lyme disease in Americans yearly. The vector-borne illnesses that Dr. Green recognizes, diagnoses and treats are relatively new and the scientific evidence is still emerging. She has devoted her time to understand how to best diagnose and treat sick patients and to share that understanding by developing evidence-based curriculum to provide other physicians continuing medical education. Over the past twenty-five years Dr. Green has treated thousands of patients with persistent tickborne disease. She serves on the boards of multiple Lyme organizations, speaks at conferences in the US and Europe, and is currently a director on the board and serves as Education Co-director of Invisible International,.https://invisible.international/ Dr. Green considers the whole patient, the scientific evidence, the clinical evidence and applies best practices on an individual basis. Dr B Robert Mozayeni, MD Expert in Translational Medicine, the science and art of advancing medical science safely and efficiently Dr. Mozayeni trained in Internal Medicine, Rheumatology and Molecular Biophysics in a physician-scientist research residency at Yale-New Haven Hospital, where Lyme disease was discovered and treated by Rheumatologists in the Rheumatology section. He subsequently became a Senior Staff Fellow at the National Institutes of Health (NIH) where he completed a second fellowship in Rheumatology. Since 1994, while in private practice, has held clinical privileges at Suburban Hospital, a member of Johns Hopkins Medicine and an affiliate of the NIH Clinical Center. Recently, he became the President of ILADS. His main objective with ILADS is the same as with his professional career – to advance the science of translational medicine and learn from the issues presented by Lyme disease, how to more rapidly advance medical science. His career passion is to find the fastest path for advancing medical science in diverse areas of patient need and controversy to validate and continuously improve best clinical practices. He is the Chief Medical Officer of Galaxy Diagnostics, LLC. Recently, he founded ‘T Lab’ focusing on the use of high resolution microscopy to identify cryptic infections and demonstrate how they cause disease. He is a Fellow of the non-profit Think Lead Innovate Foundation and he is a founder of the non-profit Foundation for the Study of Inflammatory Diseases. His work on cerebrovascular diseases, as a Rheumatologist, he began to appreciate the importance of Bartonella cryptic infections. Over the past 12 years, he has been actively researching chronic rheumatic and cerebrovascular diseases and their relationship to persistent human Bartonella infection. Dr. Natasha Rudenko, PhD. Deputy Head of the laboratory of Molecular Ecology of Vectors and Pathogens at the Institute of Parasitology of Biology Centre Academy of Sciences of the Czech Republic For the last two decades her research were focused on ecology, epidemiology, and distribution of arthropod-borne diseases and vector-host-pathogen interactions. The main interests are: ecology, epidemiology, genetic diversity of the causative agent of human Lyme disease, the spirochetes from Borrelia burgdorferi sensu lato complex, in Europe and around the world and their impact in global public health, microbial infectivity, pathogenicity, survival behaviors, and response to antibiotic treatment or capability to transform into persisting forms that cause relapsing or chronic diseases. Dr. Adam Birkenheuer Andy Quattlebaum Distinguished Chair in Infectious Disease Research at the NC State College of Veterinary Medicine, USA. Dr Birkenheuer received his DVM from the University of Florida, and his PhD in Immunology from NC State University. He is the Quattlebaum Distinguished Chair in Infectious Disease Research at the NC State College of Veterinary Medicine, USA and has widely published on tick-borne diseases. ​ Christèle Dumas-Gonnet Patient-Expert Lyme disease and co-infections Christèle Dumas-Gonnet is 49 years old and she graduated a University Degree in Therapeutic Patient Education at Faculty of Medicine of the Sorbonne University – Paris in 2021. She’s the Co-founder of the PReFacE Collective (Patient REsource FACilitator Europe). She initially graduated from Sciences Politiques Lyon and has worked for almost 20 years in the field of health, medico-social and child protection. She is also a volunteer in end-of-life support for people with brain tumors in a neuro-oncology department. Mikolaj Hurla President of student research group of neurobiology, undergraduate researcher at Neurobiology Lab, Clinic of Neurology, Poznan University of Medical Sciences (PUMS) Mikołaj Hurła is a 6th year MD student and the president of the student research group of neurobiology. He has been awarded a Chancellor's Scholarship (2021-2023) for his scientific activity. He is a member of the Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment and the Student Scientific Society. He is an active member of Prof Jolanta Dorszewska and Prof Wojciech Kozubski research team at Neurobiology Lab and Clinic of Neurology PUMS. His main interests are: neurodegenerative diseases, especially Alzheimer's Disease and its molecular basis. Recently his research concerns the involvement of infectious agents in the pathogenesis of Alzheimer’s Disease. Robert C. Bransfield, MD, DLFAPA Board certified by the American Board of Psychiatry and Neurology in Psychiatry and a Distinguished Life Fellow of the American Psychiatric Association. Dr. Bransfield’s primary activity is an office based private practice of psychiatry. In addition, Dr Bransfield is the Past President of ILADS, the International Lyme and Associated Diseases Educational Foundation and the New Jersey Psychiatric Association. He has held a number of administrative positions with organizations involved with health, mental health and community related activities. He is a Clinical Associate Professor of Psychiatry at Rutgers—Robert Wood Johnson Medical School and the Hackensack Meridian School of Medicine. Dr Bransfield has authored and co-authored a number of publications in peer-reviewed literature, other medical publications and books; has been active in political advocacy on an international, national and local level. Prof Karl Morten Principal Investigator and Director of Graduate Studies in the Nuffield Department of Women’s and Reproductive Health, Oxford University, UK. The Morten lab have a long-standing interest in understanding the role of mitochondria in health and disease and have built up over the last 15 years technologies allowing this to be studied in a high throughput format. Our research is multi-disciplinary working closely with clinicians, engineers and mathematicians. One of the leading groups in Oxford working on Mitochondria, the group collaborate widely in Oxford supporting groups to carry out experiments in this area leading to a number of publications. Recently we have been actively exploring the mechanisms behind Myalgic Encephalomyelitis/Chronic fatigue syndrome (ME/CFS) and developing compounds designed to target cancer cell mitochondria. Our plan is expand our research into other chronic conditions including Chronic Lyme Disease (CLD) and Long Covid. A small pilot study support by the Lyme Treatment Foundation has just started and looks to find evidence of persistent pathogens in CLD. The interplay between mitochondria and intracellular pathogens is likely highly important and an area we are actively exploring. Laura Lott (MBA) Chief Executive Officer, Invisible International, USA. Laura Lott is the Chief Executive Officer of Invisible International, a non-profit organization committed to alleviating the suffering caused by invisible illnesses through education, research, and community empowerment. Previously, she was the Executive Director of MIT Hacking Medicine Institute, aimed at fostering collaboration between industry, government, and academic institutions to accelerate medical innovation, as well as the co-founder and co-director of the Dean Center for Tick Borne Illness at the Spaulding Rehabilitation Hospital, an affiliate of Harvard Medical School.

< Back to Research Top Published Date 01/04/2011 The management of Ixodes scapularis bites in the upper Midwest Journal WMJ Citation WMJ. 2011 Apr;110(2):78-81; quiz 85 DOI ​ Authors Maloney EL Abstract Ixodes scapularis, commonly referred to as the deer tick, is the vector of Lyme disease and anaplasmosis; both illnesses are endemic to the upper Midwest. Avoidance of I scapularis bites is the primary preventative strategy for both infections. Antibiotic prophylaxis has been demonstrated to prevent Lyme disease, but similar studies have not investigated antibiotic prophylaxis for the prevention of anaplasmosis. Thus, recommendations regarding the management of I scapularis bites are focused on the prevention of Lyme disease. This paper reviews the prevailing antibiotic prophylaxis recommendation for Lyme disease and the evidence supporting it. Given the additional risk of acquiring anaplasmosis from an I scapularis bite in the upper Midwest, this paper proposes an alternative regimen for antibiotic prophylaxis in this region. URL Previous http://www.wisconsinmedicalsociety.org/_WMS/publications/wmj/pdf/110/2/78.pdf No Review Needed? Next

< Back Montecalvo Platform for Tick-Borne Illness Medical Education LRC 9 Nov 2021 A useful resource site we came across recently can be found here: Montecalvo Platform for Tick-Borne Illness Medical Education Invisible International: Montecalvo Foundation About the platform: Montecalvo Education Valerie and Frank Montecalvo gave a trailblazing and transformational gift to create the Montecalvo Education Platform for Tick Borne Illness. Thanks to their support, Invisible International is able to deliver the latest research on tick borne illness to physicians across the globe and enable physicians to receive free continuing medical education credits. Learn more Previous Next